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Numerous studies have highlighted the impact of oxidative stress on MSC differentiation into osteocytes [40] and chondrocytes [41] via the regulation of differentiation signaling cascades [42, 43]

Although hotspot mutation analysis is widely used in clinical and research settings, it is characterized by some limitations that may reduce sensitivity and specificity in cancer diagnosis and prognosis: i) some cancer cells may lack detectable mutations due to intratumor heterogeneity

doi: 10.1016/j.molmet.2022.101481 73 YuZPerssonHLEatonJWBrunkUT

doi:10.1186/s12967-021-02943-x 26

Kopetz S , Guthrie KA, Morris VK, Lenz HJ, Magliocco AM, Maru D, Yan Y, Lanman R, Manyam G, Hong DS, Sorokin A, Atreya CE, Diaz LA, Allegra C, Raghav KP, Wang SE, Lieu CH, McDonough SL, Philip PA, Hochster HS

Der Vitalstoff wird im Krper aus den Aminosuren Glutaminsure, Glycin und Cystein gebildet