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Due to the direct binding of Asn35 to EA, the IC 50 value of N35D was 10-fold greater than that of WT, whereas the IC 50 values of N35A and N35Q were 70- and 160-fold greater than those of WT (Table 1), indicating that the structural specificity of the side-chain of Asn35 is crucial for EA binding

Rather than serving as standalone treatments, such natural compounds are best positioned as supportive adjuvants, helping to reduce drug dosages , minimize side effects, and maintain long-term disease control in chronic, relapsing forms of psoriasis

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