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Knockdown or inhibition of E2F1 and PRMT5 in HCT116 cells was later shown to lead to reduced expression of cell migration and invasion genes (e.g

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EndMT negatively affects the functional abilities of the glomerular filtration barrier (GFB) by decreasing the production of endothelial junctional proteins and increasing the deposition of extracellular matrix (ECM) proteins (116, 117)

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However, because of the preliminary nature of these studies, the overall rating was C due to limited evidence, although one double-blind placebo-controlled study using NAC in human lead exposure was promising