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showed in their genome-wide DNA methylation study of unaffected frontal brain white matter of cALD and AMN patients that oligodendrocyte-differentiation related genes such as MBP, CNP, MOG, and PMP1 were hypermethylated and the genes of immune functions such as IFITM1 and CD59 were hypomethylated [84]

EMBO J 29(24):41854197

Certain substrates become more reactive after sulfation, a process called bioactivation

This stability is one reason oral and gastric research models exist, but stability alone does not establish oral bioavailability, clinical efficacy, or safe human use [3] 10