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This guide deliberately reports mechanisms as mechanisms

Chronic ineffective erythropoiesis leads to bone marrow hyperplasia, causing characteristic skeletal deformities such as frontal bossing, maxillary overgrowth, and thinning of cortical bone, predisposing to fractures and osteoporosis

Esto se realiza en primera instancia obteniendo cistationina (un intermediario de la cistena), mediante la CBS (Cistationina Beta Sintasa), que usa el factor pirixodal de la vitamina B6 como cofactor, formando cistationina, a partir de la Homocistena y de la Serina (un aminocido que participa en la sntesis de purinas y a su vez es precursor de la glicina)

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