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Glucose values remained within normal range, consistent with no signs of hypoglycemia in a recent clinical IGF-1 trial

In this context, Pellerin and Magistretti proposed an astrocyte-to-neuron lactate shuttle (ANLS) hypothesis where astrocytes that respond to neuronal activity (e.g

Yan et al., 2021)

Concurrently, GSH reduces Fe 3 + to Fe 2 + , which activates S 2 O 8 2 to generate highly toxic sulfate (SO 4 ) and hydroxyl radicals, inducing coordinated ferroptosis and pyroptosis in lung cancer cells 219