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doi:10.31128/AJGP/04-23-6805

Journal of the American Geriatrics Society 2002;50(4):62430

Woods KA, Camacho-Hbner C, Bergman RN, Barter D, Clark AJ, Savage MO

No Rebound Hunger or Metabolic Adaptation Appetite suppressants that work through central mechanisms (GLP-1 agonists, sympathomimetics, serotonergic agents) typically create tolerance over time, requiring dose escalation, and often produce rebound hunger when discontinued

The STEP 8 trial: direct comparison The STEP 8 trial is the most important study for this comparison because it pitted semaglutide 2.4 mg weekly directly against liraglutide 3.0 mg daily in adults with overweight or obesity but without diabetes