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It also clearly demonstrates that the role of RABGAP1 in APP trafficking is dependent on its GAP activity, suggesting that it mediates this effect through RAB protein inactivation

Corneal ulcers, Dr

Goldstein, L

Together, this evidence suggests that stress-induced BBB dysfunction associated with combat may have allowed pyridostigmine to penetrate the brain and exert central neurotoxic effects that are characteristic of Gulf War Syndrome