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10.1016/S0140-6736(14)61909-7 16 BovenschenH

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p62 competes with NRF2 for binding to KEAP1, and this interaction induces a dependent autophagic degradation of KEAP1 and subsequent NRF2 stabilization and activation in both MEFs and HEK293 cells [198]

Then, the cDNA library was constructed using the iScript cDNA synthesis kit (Biorad, cat

doi:10.1038/s41392-022-01151-3

Indeed, Kang reported that human volunteers who ingested supratherapeutic doses of APAP (80 mg/kg) excreted dramatically lower amounts of APAP oxidative (CYP450) metabolites in urine when treated with fomepizole ( Figure 21 )