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In a retrospective review of 64 patients with metastatic melanoma treated with Nivolumab plus Ipilimumab, 31 patients experienced early toxicity warranting discontinuation of treatment, and 4 of these (13%) further developed a significant irAEs 4 months after treatment cessation

10.1038/nature03029 Nature 40 LaplanteM.HorvatS.FestucciaW

It relies on Vitamin C, Vitamin E, selenium, and B-vitamins to regenerate after neutralizing free radicals

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Detection of the indicated probes was achieved using a Cytvia ImageQuant 800 biomolecular imager, and densitometric analysis was conducted using Cytvia ImageQuant400 software, with signal intensities of measured bands normalized to the intensity of whole-lane Ponceau red staining

It is an active ingredient, so it must be used properly to get the results you want