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Systemic adverse reactions are unlikely from topical administration

( A ) Flow cytometry of BODIPY-C11 stained CSE-depleted HeLa cells following treatment with RSL3 (5 M) for 4 h (left panel)

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In preclinical studies of breast cancer cell lines, inhibition of PAR-1 resulted in a significant reduction in tumor growth and metastatic lesions [135137] (Figure 4)

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Therefore, it is essential to design intelligent nano delivery platforms to enhance the bioavailability of Cur and, at the same time, leverage combined therapeutic approaches to better address the complex tumor microenvironment in vivo