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Thomas DN, Wills JW, Tracey H et al (2024) Ames test study designs for nitrosamine mutagenicity testing: qualitative and quantitative analysis of key assay parameters

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Hormones: Hormonal changes, such as those related to the menstrual cycle, pregnancy, or menopause, can cause anaemia, dark circles, and puffiness due to water retention

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10.1016/j.jmb.2020.01.025

Numbness or tingling (often described as pins and needles) typically shows up in your hands and feet first