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Morphological characteristics include reducing or disappearing mitochondrial cristae, small mitochondria with condensed mitochondrial membrane densities, and outer mitochondrial membrane rupture

We next searched for potential binding sites of REST in GCLM using JASPR, which predicted 4 sites

Hyperglycemia is associated with excessive ROS formation in mitochondria, as documented by increased DNA strand breaks

As observed, the trend line for the CON was consistently approximately twofolds higher than the corresponding SZ and BP trend line when considering total GSH level over the entire age distribution

10.1007/s12035-024-04468-y 169 Mohamed YusofN

This suggests that glutathione overproduction may be indispensable for the survival and proliferation of primary tumor cells, making the inhibition of glutathione production a promising therapeutic avenue for lymphoid tumors