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Interestingly, Insr P1195L/ + mice were extremely susceptible to overt hyperglycemia by HFD

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Even though TGFb1 treatment in aSyn-overexpressing cells did not lead to a significant increase in the intensity of caspase 3/7 signals as compared to untreated aSyn-overexpressing cells (100 7.3%), a significant decrease in caspase 3/7 signals was observed upon the knockdown of ALK5 (65.0 3.4%), SMAD2 (57.8 6.8%), or DYNLRB1 (77.3 1.3%), indicating a significant decrease in the number of apoptotic cells

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