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Spatial transcriptomics combined with Slingshot pseudo-time analysis revealed the migration trajectory of VSMC within the vascular wall: VSMC radially migrate from the media to the intima, differentiate into plaque-associated fibrocytes after passing through a myofibrillar intermediate state, and exhibit a spatial trajectory highly correlated with the gene expression gradient of ECM remodeling

5e, there was negligible COL II staining in the control group and PMI hydrogel-treated group, and increased expression of COL II was detected when TA or KGN was introduced into the hydrogel matrix

[Pituitary adenoma calcification]

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de Lau, W., Peng, W

AGEs stimulate PTECs to upregulate the expression of IL-6 and intercellular adhesion molecule 1 (ICAM-1), which induce the transmigration of macrophages, lymphocytes and mast cells into the interstitial space (52)