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doi: 10.1016/0006-8993(94)91688-8

There is, however, a caveat on the sustainability of the therapeutics as the additional beneficial effects supplemented by citicoline eye drops appear to fall back to baseline after the washout period

Preventing Receptor Desensitization Receptor desensitization is a complex cellular process where a cell's response to a stimulus decreases after repeated or prolonged exposure to that stimulus