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Consistency over the full protocol duration matters more than individual dose precision

This entire process dramatically reduces the compound's overall bioavailability compared to injection

For men who do not respond to oral medications, second-line treatments include vacuum erection devices, intracavernosal injections (alprostadil), intraurethral therapy, or penile prosthesis surgery

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This makes it particularly relevant in clinical contexts where someone has gut lining compromise alongside systemic inflammation, for example, long-term NSAID use for chronic pain

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