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Folate and SAMe 15 are both required for the proper function of the one-carbon cycle metabolic pathway, for which substantial evidence supports their involvement in mood disorders

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59,72,73 One study in pain-sensitized mice found neutrophils invaded peripheral sensory nerves and increased their pain signaling, whereas neutrophil depletion prevented the mice from developing chronic widespread pain

Peer review Peer review information Nature Reviews Clinical Oncology thanks the anonymous reviewers for their contribution to the peer review of this work

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