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Homocysteine, as noted in this article, if its too low could be too much methylation support (such as B12 and methylfolate) may cause levels to decrease too far

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While it uses the usual fructose pathways, it is not metabolized by the body

Solignat, M., Gay, B., Higgs, S., Briant, L

Most protocols use 13mcg/kg as the working range: 1mcg/kg produces measurable GH elevation with minimal desensitisation risk, 2mcg/kg generates peak amplitude responses in most subjects, and 3mcg/kg approaches the ceiling dose beyond which additional peptide does not proportionally increase GH output