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The investigators interpreted the findings as direct pharmacological validation of the NNMT-knockdown phenotype reported earlier in the Kraus 2014 genetic-validation study

In animal models of metabolic diseases, JBSNF-000028 (Ruf et al., 2022) and JBSNF-000088 (Kannt et al., 2018) were identified to inhibit human and mouse NNMT activity

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Specifically, investigations on the Chinese Han population identified the rs10891644 variant as significantly associated with obesity susceptibility, with heterozygous individuals (GT type) exhibiting heightened vulnerability (Zhou et al., 2017)

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