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456 Deficiencies in the tyrosine metabolic enzyme 4-hydroxyphenylpyruvate dioxygenase (HPD) lead to mTOR activation, promoting the accumulation of TCA cycle intermediates, such as citrate, -KG, succinate, fumarate, and malate

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Lau A, Rahn JJ, Chappellaz M, Chung H, Benediktsson H, Bihan D, et al

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Hippo/Mst signaling couples metabolic state and immune function of CD8+ dendritic cells