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Defects in SDH subunits lead to succinate accumulation and oncometabolite-driven pseudohypoxia and are strongly linked to hereditary paragangliomas, pheochromocytomas and certain renal cell carcinomas, underscoring the essential role of complex II in metabolic and redox homeostasis 78,79

Besides classical antioxidant effects, dietary phenolic compounds or metabolites thereof have been discussed as modulators of DNA transcription based on interaction with transcription factors such as Nf-B ( , cellular effects are mainly related to its anti-inflammatory and antioxidant activity and have been detailed and summarized elsewhere ( Some of these concerns can be efficiently addressed with a modified ex vivo cell culture setting

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Of particular relevance for allergies, VIP has been proposed as a therapeutic option for inflammatory allergic disorders including asthma, rhinitis, atopic dermatitis, and eosinophil-associated gastrointestinal disorders

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