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Conversely, low HDI regions had fewer cases (109,572) but extremely high mortality (58,586 deaths) ( Table 2 ), with a mortality-to-incidence ratio more than double that of high HDI regions ( Table 2 Breast cancer burden across human development index (HDI) levels

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For example, rivaroxaban protects the EG against damage caused by oxidative stress (50), doxycycline protects against sepsis-induced EG damage (51), and excessive aldosterone can cause EG damage (52)

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This cationic nature enables strong mucoadhesive interactions and contributes to its potent antimicrobial activity

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The study found that FOXO4 localizes predominantly in the cytoplasm of Leydig cells in young mice but translocates to the nucleus in aged animals the same FOXO4-p53 sequestration pattern seen in other senescent cell types

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