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The net effect: adipocytes become metabolically sluggish, oxidizing less fat, storing more energy, and resisting signals that would normally promote energy expenditure

This can occur because you consume fewer calories, which means your body has less fuel to work with

Quantifying heterogeneity in a metaanalysis

The Phase 3 OPTIONS study (536 subjects, 24 weeks) failed to show statistically significant weight loss compared to placebo

Investigational applications may include studies involving adipocyte differentiation, lipid metabolism, mitochondrial function, energy balance regulation, and controlled biochemical analysis of cellular metabolic responses under standardized experimental conditions