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EARLY WORK DEFINING THE INSULIN-GH-IGF-AXIS Daughaday realized that the mitogenic effect of GH in the growth plate was not direct but mediated by Insulin-like Growth Factor-I (IGF-I), at that time named sulphation factor or somatomedin C (1)

It can be regained if there is no swelling following the injection

Conflicts of interest Frhbeck G received honoraria from Lilly, Novo Nordisk, Regeneron, AstraZeneca and Boehringer Ingelheim as a member of advisory boards, and honoraria for lectures as a member of the OPEN Spain Initiative

They compared 13 severely obese women with a high body mass index (BMI) to 14 non-obese women of similar age

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