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In this study, we show that nearly half of the human thyroid cancer specimens have increased GPX4 expression compared to control normal thyroid tissue and that the GPX4 overexpression is associated with worse overall survival

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For example, the glutathione conjugate of hexachlorobutadiene is processed in the kidneys into reactive intermediates, leading to nephrotoxicity

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The 17 molecular consequences found in the ClinVar database, were further subjected to analysis of six insilico SNP prediction tools, SIFT, Mutation Tester, Polyphen-2, SNP&GO, PROVEAN, SNAP2, and PredictSNP to identify significant deleterious nsSNPs

Furthermore, immunostaining confirmed increased expression of LAMA1 alongside HNF4A in KO compared to WT cells (Fig