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In a study carried out in THP 1 human macrophages, metformin blunted foam cell formation induced by palmitic acid (Song et al., 2010)

Advanced oral formats such as liposomal or sublingual products improve this, but still run through the digestive system

A linear dose-dependent increase in Cat and a non-linear dose-dependent increase in Sod gene expression was found [18], in correspondence with previous research in other invertebrates [97,98,99]