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5-azacytidine (5AC) and decitabine (5-aza-2-deoxycytidine, DAC) are the prototype of the nucleoside derivatives and were approved by the US Food and Drug Administration (FDA) in 2004 and 2006 for the treatment of myelodysplastic syndrome (MDS), respectively (17, 40 42)

Arnold M, Pandeya N, Byrnes G, Renehan AG, Stevens GA, Ezzati M, et al