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additionally NAD + can be generated in the mitochondria from NMNAT3 80 , whose activity has been shown to be required in cells 77 , but dispensable in vivo as NAD + can be replenished through other pathways such as import from the cytosol 81

ADNI has standardized data acquisition across more than 60 sites, covering structural MRI, PET imaging, CSF biomarkers, genomic information, and neuropsychological assessments

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In most cases, methylcobalamin is nontoxic, even in large doses

At the core of spatial omics lies the integration of high-resolution imaging with molecular profiling, allowing the simultaneous detection of multiple biomolecular expressions within a single tissue section [286]