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The content is not intended to encourage application, diagnosis, or self-treatment of unlicensed individuals, and should not be used as a substitute for the clinical judgment of a qualified healthcare provider.

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Denileukin diftitox (Ontak), approved by the FDA in 1999 against recurrent cutaneous T-cell lymphoma, is one of the first recombinant engineered chimeric proteins that combined interleukin-2 and diphtheria toxin