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doi: 10.1016/j.healun.2015.06.012

MK-7 and vitamin K1 blunt endothelial-to-mesenchymal transition (EndMT) Persistent vascular oxidative stress promotes adverse cellular remodeling including TGF- (transforming growth factor beta)-mediated EndMT, a major hallmark of unstable atherosclerotic plaques 24,25

Methionine is converted to S-adenosylmethionine (SAM) by methionine adenosyltransferase (MAT), which then creates S-adenosylhomocysteine (SAH) via TSS.SAH is converted to homocysteine (HCY), a precursor of cysteine, by S-adenosylhomocysteine hydrolase (SAHH) (99, 100)

Therefore, we summarize the current knowledge regarding the mechanisms involved in the regulation of ferroptosis for further discussion of its role in the pathogenesis and prognosis of skin diseases

Schuster, S., Cabrera, D., Arrese, M