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(2020) showed that AS-IV (0.4, 4, 40 M) enhanced the antitumour activity of cisplatin in HCC cells by inhibiting MRP2 expression

Depakote and Depakene can cause serious side effects, including: Serious liver damage that can cause death, especially in children younger than 2 years old

In particular, controversial views have been expressed on the role of bioactivation of OTA and the relevance of OTA-derived DNA adducts (Manderville 2005

Other studies have shown how low glutathione levels may be a risk factor for paracetamol hepatotoxicity in alcoholics because a lower dose of paracetamol will be necessary to deplete GSH below the critical threshold concentration where hepatocellular necrosis starts to occur

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doi: 10.1016/j.ecoenv.2023.115112 53