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The clinical implications of these findings are substantial, and suggest that targeting GM through FMT and other microbiome-modulating therapies like prebiotics and probiotics may not only alleviate GI symptoms associated with PD but also enhance SCFAs, and anti-inflammatory cytokines (IL-6, IL-10) production, while decreasing pro-inflammatory cytokines and chemokines (MCP-1 and IL-8) (163)

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The underlying mechanism is primarily associated with inhibiting macrophage Mincle-mediated necroptosis and the inflammatory response directed towards tubular epithelial cells

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

PD patients are subjected to nutritional disorders and deficiency of certain vitamins like folate, vitamin B6 and B12

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