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66 Recently, supercritical carbon dioxide (scCO 2 ) has attracted much attention due to its lower critical temperature (31.1C) and critical pressure (73.8 bar) to solubilize some specific polymers, and the interactions of scCO 2 with the active ingredient, polymeric materials and solvents should be considered in microsphere fabrication

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However, keeping an elevated intracellular ROS level within AML cells without altering their viability and proliferation potential requires the establishment of a set of detoxification mechanisms to support their continued growth [33]

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