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While the principles regulating glucose-dependence in cancer cells have been extensively reviewed, we still do not fully understand how cancer cells use many of the metabolic strategies to contribute to core metabolic functions in the presence of nutrients different from glucose

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These include the following: Feeding problems: Because of the anatomical defects, it may be very difficult for newborn infants to breastfeed successfully

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Injection site reactions (redness, mild swelling) occur in 2535% of injections and are normal inflammatory responses that peak at 1224 hours and resolve within 48 hours