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Brain 141 (12), 344356

found that the optimal dietary copper intake (13 mg/day) was associated with a decrease in susceptibility to aortic atherosclerosis, as shown in rabbits fed with cholesterol compared with rabbits fed deficient diets (0 mg/day) and high copper supplementation (20 mg/day) [62]

When the FDA places a peptide in a restricted or high-risk category [known as Category 2], it is explicitly signaling that it has identified safety concerns and that enforcement discretion does not apply. But, as Hajduczok notes, just because something is not FDA-approved doesnt mean its illegal to compound, but the restricted peptides should not be compounded

Ashcroft FJ, Mahammad N, Midtun Flatekvl H, Jullumstr Feuerherm A, Johansen B

10.1016/j.cej.2022.141099 127 HanG.LiuS.PanZ.LinY.DingS.LiL.et al (2020)

Once reconstituted, refrigerate and use within 30 days