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There is evidence that HIF-1 plays a crucial role in the carcinogenesis process

Administration of lipopolysaccharide (LPS)-derived from gut microbiota completely abolished the antibiotic-induced neuroprotective effects in oxaliplatin-treated mice, possibly via the ligand binding of LPS to its own receptor toll-like receptor 4 (TLR4) (Shen et al., 2017)

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That was a very interesting finding given Wirths and Scheibenbogens 2021 hypothesis that calcium overload in the mitochondria could explain ME/CFS