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2.9 Glutathione content measurement Tissue samples (1.5 g) were ground in 2 mL 60 mmol L 1 sodium phosphate buffer (pH 7.0), and refrigerated centrifugation was performed at 12,000 g for 15 min, after which 100 L of supernatant was obtained

H 2 O 2 induced a 1.73.0 fold increase in NRF2 target gene expression in ATM-wt tumors (n=4), whereas induction was significantly impaired in ATM-null CLLs (n=4) (Figure 1A)

In another study, white tea improved testiscular antioxidant potential and sperm concentration, and restored sperm quality (motility, morphology and viability) in prediabetic male rats 79

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When large amounts of iron are present in the body, ROS are generated, causing lipid peroxidation, damaging the lipid membranes, and causing cell death [105]