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News links: References: Davis RE, Williams M

Contrary to HIF1-, PRL-3 does not seem to reduce OXPHOS, and recent research has shown that many hematological cancers do not downregulate OXPHOS activity (174)

Glycolysis allows GBM cells to divert glycolytic intermediates toward biosynthetic pathways such as the pentose phosphate pathway (PPP), nucleotide synthesis, and amino acid production, supporting anabolic growth and redox balance without compromising energy supply