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This vision is best exemplified by two deadly genetic diseases affecting copper concentrations in human tissues in opposed ways: Menkes disease, in which systemic copper uptake is deficient, and Wilson disease (WD), in which copper excretion from the body is blocked

The alpha factor secretion signal present in the vector facilitates the secretion of the expressed fusion peptide into the medium, simplifying purification and potential therapeutic applications

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[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Legrand J.M.D., Roy E., Ellis J.J., Francois M., Brooks A.J., Khosrotehrani K

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Niimura et al., The experimental value of zebrafish as an animal model for in vivo drug discovery has grown rapidly due to their ease of assessment, large clutch size, and ability to recapitulate human disease conditions (MacRae and Peterson, 2007