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Whereas melatonin alone significantly reduced ex vivo production of IL-5 ( Figure 6J ) and IL-13 ( Figure 6K )

doi: 10.3389/fpls.2021.766999 62 SiddiqueS.NaveedM.YaseenM.ShahbazM

Nonetheless, the aforementioned animal models, although extremely useful in investigating specific molecular mechanisms in the pathogenesis of ulcerative colitis, do not truly recapitulate disease as observed in patients, as IBD is a multifactorial disease and most clearly is not caused by a single mutation or defect in cellular or molecular pathways

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703,704 Additionally, symptomatic and supportive care, along with complication management, are important

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