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Although we can refer to many guidelines, there are many patients failed to fulfill the criteria for treatment at follow-up and eventually developed liver fibrosis, cirrhosis, and cancer (Wang et al., 2013

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For example, an alginate-chitosan coacervate nanoparticle might remain intact in the acidic stomach but then swell or dissolve at the higher pH of the small intestine, thereby releasing the payload at the desired site