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In addition, cancer cells chronically exposed to an acidic pH reveal a downregulation of the mitochondrial ACC2 isoform, the enzyme that regulates CPT1 activity by malonyl-CoA synthesis

Serial dilutions of the drugs were placed in U-bottom 96-well plates (Costar, Corning Incorporated, Kennebunk, ME, USA) in triplicate

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Anhydrides, halides or salts thereof, e.g

The results from the two approaches were highly consistent (rho = 0.991, P 0.6), assessed using Pearson or Spearman methods as appropriate, retaining the metabolite with the lower coefficient of variation in each correlated pair