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The effects of intracoronary administration of vitamin E on myocardial ischemia-reperfusion injury during coronary artery surgery

Schmidinger M, Budinsky AC, Wenzel C, Piribauer M, Brix R, Kautzky M,

Permeation experiment was carried out for 24 h at 37 C with Franz-type diffusion cells

Primary endpoint: GSH concentration in venous umbilical cord blood erythrocyte in response to NAC supplementation GSH concentrations in venous cord blood did not differ between NAC and placebo arms, whether FAS ( P 0.38) or PP ( P 1.0) populations were considered

Subsequent efforts to improve the therapeutic index led to the development of JHU083, an orally bioavailable DON prodrug, which has thus far been evaluated only in preclinical models [168]