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Charting the development timeline of these age-hallmarking pathological processes might pave the way toward more tailored and effective therapeutics that specifically target the most essential process, at the most appropriate time and in the most suitable patients

The Y receptor/NPY hormone family forms a multi-ligand/multi-receptor system in which NPY and PYY display high affinity for the hY 1 R, hY 2 R, and hY 5 R, whereas PP has the highest affinity for the hY 4 R (Pedragosa-Badia et al., 2013)