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Ethics declarations Conflict of interest SW: advisory boards and honoraria for academic talks from Bausch Health, Eli Lilly, Janssen, and Novo Nordisk

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The next step of UQ synthesis is the formation of polyisoprenoid tail of polyprenyl pyrophosphate (PPPP) in mitochondria by solanesyl diphosphate synthase (SPS3), which is trans-polyprenyl diphosphate synthase, also called Coq1

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