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Other than IDO, cancer cells can also use TDO, an immunosuppressive enzyme, to avoid immune destruction

Current treatments for liver diseases include antioxidants, hepatoprotective agents, anti-inflammatory drugs, and antivirals, all aimed at preventing or mitigating liver damage (5)

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Once cardiomyocytes are subjected to intolerable hypoxic stress or other factors, irreversible mitochondrial damage will result, which in turn leads to mitochondrial swelling, deformation, and rupture, thus directly affecting mitochondrial energy metabolism

Furthermore, the stability or expression of GSK3 protein was not significantly changed by UBR5 KD or overexpression, confirming the direct regulation of SIRT7 by UBR5 (Supplementary Fig