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Regardless of differences in study designs and diagnostic criteria, all the studies have reported significant reductions of HIT-associated symptoms as a result of DAO supplementation

Fatemi SH, Stary JM, Earle JA, Araghi-Niknam M, Eagan E (2005)

An enzyme called tyrosinase plays a key role in this process its like the factory manager that tells your melanocytes to make more melanin

The skin surface was washed with PBS to remove unbound dye, and the stained skin was excised and rapidly frozen in liquid nitrogen

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Genes with at least 10 counts in each sample were then subjected to an analysis of differential gene expression via the DESeq2 R-package 84