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Studies conducted in vitro and in animals have indicated that -tocopherol and its major metabolite, -carboxyethyl hydroxychroman (-CEHC), may play a role in protecting the body from free radical-induced damage in various conditions of oxidative stress and inflammation (reviewed in 8)

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On the 17th day, the mice were euthanized, and the tumor tissues were extracted, weighed, and preserved in 4% paraformaldehyde for subsequent investigations