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Glutathione reductase activity is lower in all colorectal carcinoma groups than in control, and a significant decrease in glutathione reductase activity was obtained between patients in tumor stage II and III compared to tumor stage IV

And they cant afford to make mistakes

The Markov chain model showed that although majority of patients in the high risk category will stay there (0.63 likelihood), a fair proportion will transition back to the intermediate risk category (0.31 likelihood)